[1]陈秀峰,姚 红.2 型糖尿病病人血浆正五聚蛋白-3 与视网膜病变的关联[J].内蒙古医科大学学报,2019,41(04):350-353.
 .ASSOCIATION BETWEEN PLASMA PENTRAXIN-3 AND RETINOPATHY IN PATIENTS WITH TYPE2 DIABETES MELLITUS[J].Acta Academiae Medicinae Neimongol,2019,41(04):350-353.
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2 型糖尿病病人血浆正五聚蛋白-3 与视网膜病变的关联()
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《内蒙古医科大学学报》[ISSN:1004-2113/CN:15-1129/R]

卷:
41
期数:
2019年04期
页码:
350-353
栏目:
出版日期:
2019-08-12

文章信息/Info

Title:
ASSOCIATION BETWEEN PLASMA PENTRAXIN-3 AND RETINOPATHY IN PATIENTS WITH TYPE2 DIABETES MELLITUS
文章编号:
2095-512X(2019)04-0350-04
作者:
陈秀峰 姚 红
山西医科大学基础医学院 免疫教研室,山西 太原 030001
Author(s):
CHEN Xiu-feng YAO Hong
Department of Immunology,School of Basic Medical Sciences,Shanxi Medical University,Taiyuan 030001 China
关键词:
2 型糖尿病视网膜病变正五聚蛋白-3
Keywords:
type2 diabeticsretinopathypentraxin-3
分类号:
R774.1
文献标志码:
A
摘要:
目的:评估 2 型糖尿病(DM)病人血浆正五聚蛋白-3(PTX-3)水平与视网膜病变的关系。方法:研 究对象包括 30 例糖尿病视网膜病变(DR)(+)病人,32 例 DR(-)和 27 例 Control 者。记录 3 组病人临床特征、 生化指标、眼科检查、C-反应蛋白(CRP)和 PTX-3 水平。结果:Control、DR(-)和 DR(+)组血浆 PTX-3 水平上 有统计学差异。Control 血浆 PTX-3 水平最低,DR(+)组血浆 PTX-3 水平最高。视网膜病变严重程度与 PTX-3 水平具有相关性。糖尿病病程较长时,DR(+)组收缩压和尿白蛋白/肌酐比(UACR)显著高于 DR(-)组。多元 逻辑分 PTX-3(P= 0.003,OR= 1.63)和收缩压(P= 0.024,OR= 1.08)是影响 DR 的因素。结论:本研究表明,血浆 PTX-3 水平与 DR 严重程度相关,可把 PTX-3 作为一种非侵入性 DR 评价标志物。
Abstract:
Objective:To evaluate the relationship between plasma level of pentraxin-3(PTX-3) and retinopathy in patients with type 2 diabetes mellitus(DM).Methods:The subjects included 30 pa tients with diabetic retinopathy(DR)(+),32 patients with DR(-)and 27 patients with Control.The clinical characteristics,biochemical indexes,ophthalmic examination,C - reactive protein (CRP )and PTX-3 levels were recorded.Results:There was significant difference between controls,DR(-)and DR (+)groups with regard to serum PTX-3 levels.Control group had the lowest and DR(+)group revealed the highest PTX-3 levels.Severity of retinopathy was related with PTX-3 levels.Duration of diabetes was longer,systolic blood pressure and urinary albumin - creatinine ratio(UACR)were significantly higher in DR(+)subjects than DR(-)subjects.Multivariate analysis revealed that PTX-3 level and systolic blood pressure were the variables that had a significant effect on DR(P = 0.003,OR= 1.63,and P = 0.024,OR= 1.08,respectively).Conclusion:This study showed that plasma PTX-3 levels was as sociated with DR severity,and PTX-3 could be used as a noninvasive marker for DR evaluation.

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备注/Memo

备注/Memo:
收稿日期:2019-04-05;修回日期:2019-07-15 作者简介:陈秀峰(1976-),女,山西医科大学基础医学院主治医师。 通讯作者:姚红,副教授,医学博士,E-mail:yyao1976@ 163.com 山西医科大学基础医学院,030001
更新日期/Last Update: 2019-09-18