[1]仝利俊1,马睿婷1,王来兵2,等.柱切换-HPLC 法测定利培酮及其代谢物的血药浓度[J].内蒙古医科大学学报,2019,41(04):344-346.
 ,,et al.DETERMINATION OF RISPERIDONE AND9-OH RISPERIDONE IN HUMAN SERUM BY COLUMN SWITCHING-HPLC[J].Acta Academiae Medicinae Neimongol,2019,41(04):344-346.
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柱切换-HPLC 法测定利培酮及其代谢物的血药浓度()
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《内蒙古医科大学学报》[ISSN:1004-2113/CN:15-1129/R]

卷:
41
期数:
2019年04期
页码:
344-346
栏目:
出版日期:
2019-08-12

文章信息/Info

Title:
DETERMINATION OF RISPERIDONE AND9-OH RISPERIDONE IN HUMAN SERUM BY COLUMN SWITCHING-HPLC
文章编号:
2095-512X(2019)04-0344-03
作者:
仝利俊1 马睿婷1 王来兵2 乔俊缠2
1.内蒙古精神卫生中心门诊,内蒙古 呼和浩特 010010; 2.内蒙古医科大学药学院
Author(s):
TONG Li-jun MA Rui-ting WANG Lai-bing et al.
Outpatient Department of Inner Mongolia National Center For Mental Health,Hohhot 010010 China
关键词:
柱切换法高效液相色谱法利培酮血药浓度
Keywords:
column switchingHPLCrisberidoneserum drug concentration
分类号:
R446
文献标志码:
A
摘要:
目的:建立柱切换高效液相色谱法测定利培酮及其代谢物的血药浓度方法学。方法:采用柱切换法 对利培酮及其代谢物血药浓度进行测定,并对利培酮及 9-OH 利培酮柱切换-HPLC 方法学进行验证。结果:柱 切换-HPLC 法线性良好,利培酮(RIS)及其产物 9-OH 利培酮(9-OHRIS)线性范围均为 4 ~ 160μg / L,方法回收 率分别为88.3% ~ 115.7%及81.9% ~ 106.8%,日内 RSD 分别为1.29% ~ 2.01%及1.62% ~ 3.41%,日间 RSD 分别为 2.19% ~ 3.10%及2.02% ~ 4.69%,重复性为2.05%。结论:柱切换-HPLC 法能够快捷准确的测定临床样本,为病人 提供更加准确及时的服务。
Abstract:
Objective:A method for determination of risperidone and its metabolites by column switching HPLC was established.Methods:The plasma concentration of risperidone and its metabolites was determined by column switching method,and verified the column switching-HPLC method of ris peridone and 9-OH risperidone.Results:The Column Switching-HPLC method which used on RIS and 9-OHRIS have a linear range of 4 to 160μg / L,with recovery rates of 88.3% ~ 115.7%and 81.9% ~ 106.8%,respectively.The RSD during the day was 1.29% ~ 2.01%and 1.62% ~ 3.41%,and the RSD during the day was 2.19% ~ 3.10% and 2.02% ~ 4.69%,Repeatability is 2.05%. Conclusion:The column switching-HPLC method can quickly and accurately determine clinical samples and provide patients with more accurate and timely services.

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备注/Memo

备注/Memo:
收稿日期:2019-04-17;修回日期:2019-07-08 基金项目:自治区卫生计生科研计划项目(201703075) 作者简介:仝利俊(1976-),男,内蒙古自治区精神卫生中心副主任医师,医学硕士。 通讯作者:乔俊缠,教授,硕士研究生导师,E-mail:qiaojunchan@ 163.com 内蒙古医科大学药学院,010110
更新日期/Last Update: 2019-09-18