[1]包晶晶,达林泰,乌兰其其格.结缔组织生长因子的研究进展[J].内蒙古医科大学学报,2013,35(02):164-168.
 BAO Jing-jing,DA Lin-tai,WU Lanqiqige.RESEARCHPROGRESSOF CONNECTIVETISSUEGROWTHFACTOR[J].Acta Academiae Medicinae Neimongol,2013,35(02):164-168.
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结缔组织生长因子的研究进展()
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《内蒙古医科大学学报》[ISSN:1004-2113/CN:15-1129/R]

卷:
第35卷
期数:
2013年02期
页码:
164-168
栏目:
综述
出版日期:
2013-02-28

文章信息/Info

Title:
RESEARCHPROGRESSOF CONNECTIVETISSUEGROWTHFACTOR
作者:
包晶晶 1 达林泰 2 乌兰其其格 2
1. 内蒙古医科大学,内蒙古呼和浩特010059;2. 内蒙古医科大学附属医院口腔科
Author(s):
BAO Jing-jingDA Lin-taiWU Lanqiqige
Inner MongoliaMedical University,Hohhot 010050China
关键词:
结缔组织生长因子(CTGF)TGF-茁信号途径生物学功能
Keywords:
connectivetissuegrowthfactortransforminggrowthfactor betasignalingpathwaysbi鄄 ological function
分类号:
R78
摘要:
结缔组织生长因子(connective tissue growthfactor,CTGF)是即刻早期基因CCN家族成员。 CTGF在 人类多种组织器官中广泛表达,即发育与分化、雌性生殖系统、血管生成、伤口修复、纤维变性病变、炎性病变、肿 瘤的发生发展、骨的形成与修复等多种生物学过程中起重要的作用。 在机体内几乎全部类型的成纤维细胞中诱 导CTGF表达的主要因子为TGF-茁。 TGF-茁可通过多种信号途径诱导CTGF表达,主要有4种途径,其中最重 要的是Smad介导的TGF-茁 1 途径。 CTGF的生物学功能与作用机制非常复杂,本文将对CTGF的基本结构、表 达调控、影响因素以及生物学功能研究进展进行综述,为CTGF全面解析奠定基础。
Abstract:
Connectivetissuegrowthfactor(CTGF)is amember of theCCNfamilyimmediateearly gene. CTGF is widely expressed in many human tissues and organs,the development and differentiation,thefemalereproductivesystem,angiogenesis,woundrepair,fibrosis lesions,inflammatory lesions,tumor development,bone formation and repair,its play an important role in a variety of biological processes. Induces the expression of CTGF in the machine body for almost all types of fibroblasts mainfactor is TGF-茁. TGF-茁induced CTGFexpression through a variety of signaling pathways,mainlythereare four kinds of ways,the most important of whichis the Smads of TGF-茁1 mediatedpathway. CTGFbiological functionandmechanismof actionis verycomplex,inthis paper,the basic structure of CTGF,expression and regulation,influencing factors and biological function of progress werereviewed,andlaythefoundationfor acomprehensiveanalysis of CTGF.

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更新日期/Last Update: 2013-04-20