[1]阿斯楞,仝林虎,林靖.CD105与Ang-2在大肠癌中的表达及临床意义[J].内蒙古医科大学学报,2013,35(02):102-107,114.
 A Si-leng,TONG Lin-hu,LIN Jing.EXPRESSIONANDCLINICALSIGNIFICANCE OFCD105ANDANG-2INCOLORECTALCANCER[J].Acta Academiae Medicinae Neimongol,2013,35(02):102-107,114.
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CD105与Ang-2在大肠癌中的表达及临床意义()
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《内蒙古医科大学学报》[ISSN:1004-2113/CN:15-1129/R]

卷:
第35卷
期数:
2013年02期
页码:
102-107,114
栏目:
论著
出版日期:
2013-02-28

文章信息/Info

Title:
EXPRESSIONANDCLINICALSIGNIFICANCE OFCD105ANDANG-2INCOLORECTALCANCER
作者:
阿斯楞 1 仝林虎 1 林靖
1. 内蒙古医科大学附属医院普外科,内蒙古呼和浩特010050;2. 内蒙古医科大学附属医院重症医学科
Author(s):
A Si-lengTONG Lin-huLIN Jing
Department of General Surgery,AffiliatedHospital,Inner MongoliaMedical University,Hohhot 010050China
关键词:
大肠癌CD105血管生成素2血管生成
Keywords:
normal colorectal tissues was significantlyhigher thanthat markedbyanti-CD34(P<0. 01). (3)Ang-2expressionwas significantly correlatedwithCD105 expressionbut not withCD34 expression(P< 0. 01P>0. 05). (4)The MVDmarkedby anti-CD105 andthe expressionof Ang-2 were closely associatedwithinvasivedepth、lymphonodemetastasis andDukes stages of CRC(P<0. 01)andwere not associatedwithgender 、ageanddifferential degreeof CRC(P>0. 05). Conclusion:(1)CD105and Ang-2 were associated with angiogenesis of CRCthey had a coordinated effect in the growth infiltrationandmetastasis of CRC. (2)TheMVDmarkedbyCD105canbeconsideredas animportant indexwhich is associated with tumor growthmetastasis and prognosis. CD105 used as an valuable marker of angiogenesis has important clinical significance for early diagnosisjudgement prognosis and complextreatment of CRC
分类号:
R736.3
摘要:
目的:探讨CD105和血管生成素2(Angiopoietin-2,Ang-2)在大肠癌中的表达和相互关系,以及它 们在血管生成中的作用;探讨CD105作为肿瘤新生血管标记物的可能性及临床价值。 方法:运用免疫组织化学 技术检测CD105,Ang-2和CD34蛋白在80例大肠腺癌组织和40例正常肠组织中的表达情况,并计算微血管密 度(Microvessel density,MVD),分析其表达与临床病理因素之间的关系。 结果:(1)MVD及Ang-2在大肠癌组织 与正常肠组织间表达的差异具有非常显著性意义(P<0.01,P<0.01);(2)以CD105和CD34测得的MVD差异具 有非常显著性意义(P<0.01);(3)Ang-2在大肠癌中的表达与CD105的表达呈显著正相关(P<0.01),而与 CD34的表达无关(P>0.05);(4)大肠癌组织中以CD105测得的MVD和Ang-2的表达与浸润深度、淋巴结转移 及Dukes 分期有关,差异具有非常显著性意义(P<0.01);而与性别、年龄及分化程度无关(P>0.05)。 结论:(1) CD105和Ang-2均与大肠癌血管生成有关,二者协同在大肠癌生长、浸润及转移过程中发挥重要作用;(2) CD105在大肠癌组织新生血管中有良好表达,以CD105测得的MVD可以被认为是与肿瘤生长、转移及预后有关 的一项重要指标;CD105作为大肠癌新生血管有价值的标志物,对于大肠癌的早期诊断、判断预后和综合治疗具 有重要临床意义
Abstract:
Objective:To determine the expression of CD105 and Ang-2 and the correlation betweenthemincolorectal cancer(CRC),andto determine their effect inangiogenesis. To determine theprobability and clinical value of CD105 as a marker of tumor-related angiogenesis. Methods: Immuno-histochemical technique was used to detect the expression of CD105、Ang-2 and CD34 proteinin80cases of colorectal cancer and40cases of normal colorectal tissues,thentocount themi鄄 crovessel density(MVD)andanalysis therelationshipbetweentheexpssionandclinicopathological pa鄄 rameters. Results:(1)TheMVDandtheexpressionof Ang-2inCRCtissues weresignificantlyhigher thanthoseinnormal colorectal tissues(P<0. 01). (2)The MVDmarkedby anti-CD105inCRCand

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更新日期/Last Update: 2013-04-20